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Important Information

Fioricet Precautions and Contraindications

While Fioricet is a highly effective pain reliever, it has been associated with an increased risk of addiction when used improperly, or for too long.

Never take Fioricet in greater doses, or for a longer period of time, than recommended by your doctor.

Fioricet may not be suitable for some patients, and some conditions require that this medication be taken in lower doses or with other precautions.

Discuss a history of any of the following conditions with your doctor so that your treatment will be as safe as possible.

  • Alcohol or drug abuse: You may be at an increased risk for liver damage or dependence.

  • Allergic reaction to any barbiturate, acetaminophen, or caffeine: Do not take Fioricet.

  • Asthma: Increased risk of serious side effects

  • Depression: Butalbital may worsen this condition

  • Diabetes (sugar): Butalbital may worsen this condition

  • Heart disease: Caffeine may make certain heart conditions worse

  • Hepatitis or other liver damage: Increased risk of serious side effects

  • Hyperactivity (children): Increased risk of serious side effects

  • Kidney disease: Increased risk of serious side effects

  • Overactive thyroid: Butalbital may worsen this condition

  • Porphyria: Butalbital is listed as an unsafe drug for porphyria, an enzyme deficiency that can cause fragile skin that is sensitive to sunlight, digestive difficulties, anxiety, and reddish-brown urine.

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